Hubungan Ekspresi CDK4 dengan Karakteristik Klinikopatologis Kasus Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma dan Dedifferentiated Liposarcoma
(1) Fakultas Kedokteran Universitas Diponegoro, Semarang, Indonesia
(2) Fakultas Kedokteran Universitas Diponegoro, Semarang, Indonesia
(3) Fakultas Kedokteran Universitas Diponegoro, Semarang, Indonesia
(4) Fakultas Kedokteran Universitas Diponegoro, Semarang, Indonesia
(5) Fakultas Kedokteran Universitas Diponegoro, Semarang, Indonesia
(*) Corresponding Author
Abstract
Latar Belakang: Atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDLPS) meliputi 40-45% kasus tumor ganas jaringan adiposa, sementara Dedifferentiated liposarcoma (DDLPS) merupakan sarkoma pleomorfik terbanyak pada retroperitoneum. Keduanya memiliki kelainan genetik serupa yaitu amplifikasi 12q14-q15, dengan ekspresi berlebih MDM2 (12q15) sebagai pencetus tumorigenesis. Koamplifikasi gen CDK4 (12q14.1) sering ditemukan pada ALT/WDLPS dan DDLPS, namun hubungannya dengan karakteristik klinikopatologis ALT/WDLPS dan DDLPS masih belum diketahui. Penelitian ini bertujuan membuktikan dan menganalisis hubungan ekspresi CDK4 dengan karakteristik klinikopatologis pada ALT/WDLPS dan DDLPS.
Metode: Studi observasional analitik dengan desain potong lintang menggunakan sampel histopatologi ALT/WDLPS dan DDLPS di RS Kariadi selama periode Januari 2019-Desember 2023. Data ekspresi imunohistokimia CDK4 dianalisis bersama data karakteristik klinikopatologis pasien yaitu usia, ukuran tumor, lokasi anatomik, subtipe histologi tumor pada ALT/WDLPS, dan grading FNCLCC menggunakan uji Chi-Square dan uji T tidak berpasangan atau Mann-Whitney.
Hasil: Didapatkan 36 sampel yaitu 18 kasus ALT/WDLPS dan 18 kasus DDLPS. CDK4 positif pada 12 kasus ALT/WDLPS (7 subtipe adipositik, 4 subtipe sklerotik, dan 1 subtipe inflamatorik) dan 17 kasus DDLPS (p=0,035 dan 0,024, bermakna). Tidak ditemukan hubungan bermakna ekspresi CDK4 dengan usia, ukuran tumor, dan grading FNCLCC pada ALT/WDLPS dan DDLPS, subtipe pada ALT/ WDLPS, serta lokasi pada DDLPS, namun terdapat hubungan bermakna antara ekspresi CDK4 dengan lokasi tumor pada ALT/WDLPS (p=0,019).
Kesimpulan: Ekspresi imunohistokimia CDK4 memiliki hubungan bermakna dengan tipe histologi ALT/WDLPS dan DDLPS, serta lokasi tumor pada ALT/WDLPS.
Keywords
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DOI: https://doi.org/10.26714/medart.7.1.2025.8-18
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Faculty of Medicine, Universitas Muhammadiyah Semarang
Jl. Kedungmundu Raya No. 18, Semarang, Indonesia
Email: medica.arteriana@unimus.ac.id