Hubungan Jenis Kelamin dan Gambaran Klinis Celah Bibir Non Sindromik di CLP Center FK UMM

Ruby Riana Asparini(1*), Erika Yuli Susanti(2), Gita Sekar Prihanti(3)


(1) FK UMMalang, Malang, East Java, Indonesia
(2) FK UMMalang, Malang, East Java, Indonesia
(3) FK UMMalang, Malang, East Java, Indonesia
(*) Corresponding Author

Abstract


Relationship between Sex and Clinical Features of Non-Syndromic Cleft Lip at CLP Center FK UMM

Background: Non-syndromic cleft lip is a type of cleft that is not accompanied by abnormalities in the head and neck. There are sex differences in the timing of palate closure.

Objective: To determine the relationship between sex and clinical features of non-syndromic cleft lip (with or without cleft palate) at CLP Center FK UMM (2016-2017).

Method: CrossSectional. Data on sex and clinical features of non-syndromic cleft lip were obtained from the CLP Center FK UMM as many as 241 out of 271. Data analysis used the chi-square test with conditions
expectedcount less than five not more than 20%. If it does not meet the requirements use the non-parametric Mann Whitney test.

Results: The results of the chi-square test data analysis did not meet the requirements so that a non-parametric Mann Whitney test was carried out which showed p = 0.152 (p> 0.05), which means that there is no sex relationship and clinical features of cleft lip (with or without cleft palate). ) non-syndromic.

Conclusion: There is no sex relationship and the clinical picture of cleft lip (with or without cleft palate) is non-syndromic.



Latar Belakang: Celah bibir non sindromik merupakan jenis celah yang tanpa disertai kelainan pada kepala dan leher. Terdapat perbedaan jenis kelamin terhadap waktu penutupan langit-langit.

Tujuan: Mengetahui hubungan jenis kelamin dan gambaran klinis celah bibir (dengan atau tanpa celah langit-langit) non sindromik di CLP Center FK UMM (tahun 2016-2017).

Metode:  CrossSectional. Data jenis kelamin serta gambaran klinis celah bibir non sindromik yang diperoleh dari CLP Center FK UMM sebanyak 241 dari 271. Analisis data menggunakan uji chi-Squaredengan syarat
expectedcountkurang dari lima tidak lebih dari 20%. Jika tidak memenuhi syarat menggunakan uji non parametrikMann Whitney.

Hasil: Hasil analisis data uji chi-Squaretidak memenuhi syarat sehingga dilakukan uji non parametrikMann Whitney yang menunjukkan p=0,152 (p>0,05), yang berarti tidak ada hubungan jenis kelamin dan gambaran klinis celah bibir (dengan atau tanpa celah langit-langit) non sindromik.

Kesimpulan: Tidak terdapat hubungan jenis kelamin dan gambaran klinis celah bibir (dengan atau tanpa celah langit-langit) non sindromik.


Keywords


Celah Bibir; Celah Bibir dan Langit-langit; Non sindromik; Jenis Kelamin

Full Text:

PDF

References


Kawalec A, Nelke K, Pawlas K, Gerber H. Risk factors involved in orofacial cleft predisposition-review. Open Med. 2015;10(1):163–75.

Murthy J, Bhaskar L. Current concepts in genetics of nonsyndromic clefts. Indian J Plast Surg [Internet]. 2009;42(1):68. Available from: http://www.ijps.org/text.asp?2009/42/1/68/53004

Mossey PA, Little J, Munger RG, Dixon MJ, Shaw WC. Cleft lip and palate. Lancet. Elsevier Ltd; 2009;374(9703):1773–85.

Scheller K, Kalmring F, Schubert J. Sex distribution is a factor in teratogenically induced clefts and in the anti-teratogenic effect of thiamine in mice, but not in genetically determined cleft appearance. J Cranio-Maxillofacial Surg [Internet]. Elsevier Ltd; 2016;44(2):104–9. Available from: http://dx.doi.org/10.1016/j.jcms.2015.10.025

Moreira HSB, Machado RA, de Aquino SN, Rangel ALCA, Júnior HM, Coletta R Della. Epidemiological features of patients with nonsyndromic cleft lip and/or palate in Western Parana. Brazilian J Oral Sci. 2016;15(1):39–44.

Kosowski TR, Weathers WM, Wolfswinkel EM, Ridgway EB. Cleft Palate. 2012;1(212):164–9. http://jurnal.unimus.ac.id

Hubungan Jenis Kelamin dan Gambaran Klinis Celah Bibir Non Sindromik di Clp Center FK UMM 29 Vol. 1 No.5 Agustus 2018

Riana R. Distribusi Sumbing Bibir Dan Langit-Langit Di Cleft Lip and Palate Center Fakultas Kedokteran Universitas Muhammadiyah Malang Indonesia. Saintika Med. 2016;11(2):76–7.

Dornelles F, Cuozzo M, Espinosa MM, Tavares K. Cleft lip and palate in a Brazilian subpopulation Cleft lip and palate in a Brazilian subpopulation. J Int Oral Heal. 2013;5(4):15–20.

Lipinski RJ, Holloway HT, O’Leary-Moore SK, Ament JJ, Pecevich SJ, Cofer GP, et al. Characterization of subtle brain abnormalities in a mouse model of hedgehog pathway antagonist-induced cleft lip and palate. PLoS One. 2014;9(7):3–9.

Martelli DRB, Machado RA, Swerts MSO, Rodrigues LAM, de Aquino SN, Martelli Júnior H. Non sindromic cleft lip and palate: Relationship between sex and clinical extension. Braz J Otorhinolaryngol [Internet]. Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial; 2012;78(5):116–20. Available from: http://dx.doi.org/10.5935/1808-8694.20120018


Article Metrics

Abstract view : 1386 times
PDF - 356 times

DOI: https://doi.org/10.26714/magnamed.1.5.2018.20-29

Refbacks

  • There are currently no refbacks.




 Creative Commons License

MAGNA MEDIKA by APKKM is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Attention:

  1. We invite authors to submit manuscripts to our journal through official announcements on the journal's website, communication through associations, and personal communication with authors who have expertise in accordance with the objectives and scope of our journal.
  2. We do not offer fast publication, fast reviews, or acceptance guarantees.