Latar Belakang: Angka kejadian gastritis di Indonesia adalah 40,8% penyebab tersering adalah konsumsi Obat Anti Inflamasi Non Steroid (OAINS) dalam jangka panjang. Faktor pemicu tukak lambung yaitu sel parietal mensekresi asam hidroklorida kondisi ini bisa berlanjut permeabilitas kapiler meningkat dan perdarahan.

Metode: Penelitian menggunakan eksperimen pra klinik dengan posttest only design. Sampel 11 tikus galur Wistar betina umur 3-4 bulan, berat badan 100-250 gram. Induksi tukak lambung menggunakan asetosal 5% dosis 1500 mg/kg BB. Pemeriksaan leukosit menggunakan automatic hematology analyzer. Pemeriksaan laju endap darah menggunakan metode Westergren. Pemeriksaan makroskopi dengan menghitung jumlah ulkus dan perdarahan pada mukosa lambung.

Hasil: Hasil penelitian menunjukkan kerusakan mukosa lambung dimulai dari hipoksemia, perdarahan dan kemudian terjadi ulkus. Rata-rata kadar leukosit 14.800/cmm dan rata-rata laju endap darah 18.18 mm/jam, rata-rata jumlah perdarahan 2.45. Rata-rata jumlah ulkus 3,55.   

Kesimpulan: Induksi Asetosal pada tikus wistar menyebabkan gambaran kerusakan lambung.

Handayani M, Thomy TA. Hubungan frekuensi, jenis dan posrsi makan dengan kejadian gastritis pada remaja. Jurnal Kesehatan Saelmakers Perdana. 2018;1(2):40-45.

Rini hapsari E, Widyayastani FA, Tarius A. Efek gastroprotektor senyawa analog kurkumin terhadap jaringan lambung tikus yang diinduksi parasetamol. Media Farmasi Indonesia. 2018;13(1):1318-1323.

Narayanan M, Reddy KM, Marsicano E. Peptic ulcer disease and helicobacter pylori infection. Missouri Medicine. 2018;115(3):219-224.

Engevik AC, Kaji I, Goldenring JR. The physiology of the gastric parietal cell. Physiol Rev. 2020;100(2):573-602.

Rai M, Pandit R, Paralikar P, Nagaonkar D, Rehman F, Rai M. Pharmaceutical applications of curcumin - loaded nanoparticles. In: Rai M, Santos CAD, editors. Nanotechnology Applied To Pharmaceutical Technology. Springer. 2017.p.139-154.

Rai M, Pandit R, Paralikar P, Nagaonkar D, Rehman F, Rai M. Pharmaceutical applications of curcumin - loaded nanoparticles. In: Rai M, Santos CAD, editors. Nanotechnology Applied To Pharmaceutical Technology. Springer. 2017.p.1-386.

Matsui H, Shimokawa O, Kaneko T, Nagano Y, Rai K, Hyodo I. The pathophysiology of non-steroidal anti-inflammatory drug (nsaid)-induced mucosal injuries in stomach and small intestine. J Clin Biochem Nutr. 2011;48(2):107-111.

Sanchez LC. Disorders of the gastrointestinal system. Equine Internal Medicine. 2018:709-842.

Kee JL, Hayes ER. Farmakologi - pendekatan proses keperawatan. In: Asih Y,editor. Jakarta: EGC. 1996.

Parhan P, Gulo AY. Pengaruh kecepatan pembentukan tukak lambung terhadap pemberian berbagai golongan nsaid pada tikus jantan. J Farm. 2019;1(2):8-17.

Li K, Gesang L. Oxidative stress is associated with the gastric mucosa lesion of the Tibetans with high-altitude polycythemia. Int J Clin Exp Med. 2019;12(3):2503-2510.

Tytgat G. Etiopathogenetic principles and peptic ulcer disease classification. Dig Dis. 2011;29:454-458.

El-Meligy RM, Awaad AS, Soliman GA, Kenawy SA, Alqasoumi SI. Prophylactic and curative anti-ulcerogenic activity and the possible mechanisms of action of some desert plants. Saudi Pharm J. 2017;25(3):387-396.

Dionisio KL, Phillips K, Price PS, Grulke CM, Williams A, Biryol D, et al. Data Descriptor: The Chemical and Products Database, a resource for exposure-relevant data on chemicals in consumer products. Sci Data. 2018;5(1):1-9.

Zulaikhah ST. The Role of Antioxidant to Prevent Free Radicals in The Body. Sains Med J Kedokt dan Kesehat. 2017;8(1):39-45.

Flower R. What are all the things that aspirin does?. BMJ. 2003; 327(7415):572-573.

Lee HS, Liu KH, editors. Drug metabolism, pharmacokinetics and bioanalysis. Switzerland:MDPI;2018.

Islamy ASE, Widyarini S. 2019. Pengaruh pemberian ekstrak kulit pisang (musa paradisiaca var. kepok) sebagai gastroprotektor pada tikus wistar yang diinduksi asetosal. [Skripsi]. Yogyakarta: Universitas Gadjah Mada.

Pizzino G, Irrera N, Cucinotta M, Pallio G, Mannino F, Arcoraci V, et al. Oxidative stress: harms and benefits for human health. Oxidative Medicine and Cellular Longevity. 2017;2017:1-13.

Sharifi-Rad M, Kumar NVA, Zucca P, Varoni EM, Dini L, Panzarini E, et al. Lifestyle, oxidative stress, and antioxidants: back and forth in the pathophysiology of chronic diseases. Front Physiol. 2020;11(694):1-21.

Domínguez R, Pateiro M, Gagaoua M, Barba FJ, Zhang W, Lorenzo JM. A comprehensive review on lipid oxidation in meat and meat products. Antioxidants (Basel). 2019;8(10):1-31.

Ayala A, Muñoz MF, Argüelles S. Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. Oxidative Medicine and Cellular Longevity. 2014;2014:1-30.

Dhama K, Latheef SK, Dadar M, Samad HA, Munjal A, Khandia R, et al. Biomarkers in stress related diseases/ disorders: diagnostic, prognostic, and therapeutic values. Front Mol Biosci. 2019;6(91):1-50.

Judaki A, Rahmani A, Feizi J, Asadollahi K, Ahmadi MRH. Curcumin in combination with triple therapy regimes ameliorates oxidative stress and histopathologic changes in chronic gastritis - associated helicobacter pylori infection. Arq Gastroenterol. 2017; 54(3):177-182.

Rao USM, Ahmad BA, Mohd KS, Zin T. Antiulcer activity of musa paradisiaca (banana) tepal and skin extracts in ulcer induced albino mice. Malaysian J Anal Sci. 2016;20(5):1203-1216.

Leick M, Azcutia V, Newton G, Luscinskas FW. Leukocyte recruitment in inflammation: basic concepts and new mechanistic insights based on new models and microscopic imaging technologies. Cell Tissue Res. 2014;355(3):647-656.

Melit LE, Marginean MO, Mocan S, Marginean CO. The usefulness of inflammatory biomarkers in diagnosing child and adolescent’s gastritis: strobe compliant article. Medicine (Baltimore). 2019;98(26):e16188:1-5.