Literatur Review: Terapi Plasma Konvalesen Bagi Pasien Covid-19

Francisca Romana Sri Supadmi(1*)


(1) [SINTA ID: 6065747] Universitas Jendral Achmad Yani Yogyakarta
(*) Corresponding Author

Abstract


Latar Belakang: Coronavirus Disease 2019 (COVID-19) disebabkan oleh Sars-CoV-2 termasuk jenis virus corona, merupakan penyakit yang menyebabkan gangguan pernapasan akut dengan masa inkubasi rata-rata 5 hingga 14 hari. Pada kasus COVID-19 berat dapat menyebabkan pneumonia, sindrom pernapasan akut, gagal ginjal, dan bahkan kematian. Berbagai upaya telah dilakukan guna mencegah penyebaran infeksi, dengan dikeluarkannya berbagai protokol pencegahan dan penatalaksanaan terhadap pasien terinfeksi salah satunya terkait penggunaan plasma konvalesen sebagai terapi suportif. Penelitian ini bertujuan untuk melihat bagaimana prosedur penggunaan plasma konvalesen untuk terapi suportif pasien Covid-19

Metode: Jenis dan rancangan penelitian ini adalah literature review. Data yang digunakan adalah data sekunder berupa artikel atau jurnal dari penelitian terdahulu yang relevan dengan topik penelitian. Staregi pencarian data menggunakan database Google Scholar dan Pubmed. Seleksi studi dilakukan untuk menentukan artikel yang akan direview. Hasil catatan informasi dari artikel yang ditelaah disusun dalam tabel ektrasi data. Hasil literature review dianalisis dengan menggunakan tema sesuai temuan dari artikel.

Hasil: Hasil review, dengan terapi plasma konvalesen bagi pasien Covid-19 terdapat perbaikan tanda dan gejala, peningkatan PAO2/FIO2, perbaikan gambaran radiologi, peningkatan titer antibodi IgM dan IgG, pemulihan kondisi secara umum dan kesembuhan hingga pasien boleh pulang dari rumah sakit.

Kesimpulan: Terapi plasma konvalesen efektif memperbaiki dan mengobati Covid-19.


Keywords


Covid-19, SARS-CoV-2, Terapi Plasma Konvalesen

Full Text:

PDF

References


Ahn, J. Y., Sohn, Y., Lee, S. H., Cho, Y., Hyun, J. H., Baek, Y. J., … Choi, J. Y. (2020). Use of convalescent plasma therapy in two Covid-19 patients with acute respiratory distress syndrome in Korea. Journal of Korean Medical Science. https://doi.org/10.3346/JKMS.2020.35.E149

Anudeep, T. C., Jeyaraman, M., Shetty, D. U., Raj, H., Ss, A., Somasundaram, R., … Dilip, J. (2020). Convalescent Plasma as a Plausible Therapeutic Option for nCOVID-19-A Review. 10(1000409), 1–7. https://doi.org/10.35248/2167-0870.20.10.409

Boopathi, S., Poma, A. B., & Kolandaivel, P. (2020). Novel 2019 Coronavirus Structure, Mechanism of Action, Antiviral drug promises and rule out against its treatment. Journal of Biomolecular Structure and Dynamics, (April), 1–14. https://doi.org/10.1080/07391102.2020.1758788

Chan, J. F. W., Kok, K. H., Zhu, Z., Chu, H., To, K. K. W., Yuan, S., & Yuen, K. Y. (2020). Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan. Emerging Microbes and Infections, 9(1), 221–236. https://doi.org/10.1080/22221751.2020.1719902

Cheng, Y., Wong, R., Soo, Y. O. Y., Wong, W. S., Lee, C. K., Ng, M. H. L., … Cheng, G. (2005). Use of convalescent plasma therapy in SARS patients in Hong Kong. (March 2003), 44–46. https://doi.org/10.1007/s10096-004-1271-9

Clinical, W. H. O., & Who, W. (2020). World Health Organization. Clinical management of severe acute respiratory infection when novel coronavirus (2019-nCoV) infection is suspected: interim guidance. Who. Retrieved from https://www.who.int/publications-detail/clinical-management-of-severe-acute-respiratory-infection-when-novel-coronavirus-(ncov)-infection-is-suspected

Gugus Tugas Percepatan Penanganan Covid-19. (2020). Pedoman Penanganan Cepat Medis dan Kesehatan Masyarakat Covid-19 di Indonesia. In 23 Maret.

Guo, Y. R., Cao, Q. D., Hong, Z. S., Tan, Y. Y., Chen, S. D., Jin, H. J., … Yan, Y. (2020). The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak- A n update on the status. Military Medical Research, 7(1), 1–10. https://doi.org/10.1186/s40779-020-00240-0

Huang, C., Wang, Y., Li, X., Ren, L., Zhao, J., Hu, Y., … Cao, B. (2020). Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. The Lancet. https://doi.org/10.1016/S0140-6736(20)30183-5

Kemenkes RI. (2020). Pedoman Pencegahan dan Pengendalian Coronavirus Disease (COVID-19). Germas. Retrieved from https://www.kemkes.go.id/resources/download/info-terkini/COVID-19 dokumen resmi/2 Pedoman Pencegahan dan Pengendalian Coronavirus Disease (COVID-19).pdf

Khailany, R. A., Safdar, M., & Ozaslan, M. (2020). Genomic characterization of a novel SARS-CoV-2. Gene Reports. https://doi.org/10.1016/j.genrep.2020.100682

Kwon, S. Y., Kim, E. J., Jung, Y. S., Jang, J. S., & Cho, N. S. (2020). Post-donation COVID-19 identification in blood donors. Vox Sanguinis. https://doi.org/10.1111/vox.12925

Monterrey, H. S. J. T. de, & Monterrey, T. de. (2020). Safety in Convalescent Plasma Transfusion to COVID-19. ClinicalTrials.

Mousavizadeh, L., & Ghasemi, S. (2020). Genotype and phenotype of COVID-19: Their roles in pathogenesis. Journal of Microbiology, Immunology and Infection, (xxxx), 0–4. https://doi.org/10.1016/j.jmii.2020.03.022

Shen, C., Wang, Z., Zhao, F., Yang, Y., Li, J., Yuan, J., … Liu, L. (2020a). Treatment of 5 Critically Ill Patients with COVID-19 with Convalescent Plasma. JAMA - Journal of the American Medical Association, 323(16), 1582–1589. https://doi.org/10.1001/jama.2020.4783

Shen, C., Wang, Z., Zhao, F., Yang, Y., Li, J., Yuan, J., … Liu, L. (2020b). Treatment of 5 Critically Ill Patients with COVID-19 with Convalescent Plasma. JAMA - Journal of the American Medical Association. https://doi.org/10.1001/jama.2020.4783

Sohrabi, C., Alsafi, Z., O’Neill, N., Khan, M., Kerwan, A., Al-Jabir, A., … Agha, R. (2020). World Health Organization declares global emergency: A review of the 2019 novel coronavirus (COVID-19). International Journal of Surgery. https://doi.org/10.1016/j.ijsu.2020.02.034

Suni, N. S. P. (2020). Kesiapsiagaan Indonesia Menghadapi Potensi Penyebaran Corona. Pusat PenelitianBadan Keahlian DPR RI.

Tian, S., Hu, N., Lou, J., Chen, K., Kang, X., Xiang, Z., … Zhang, J. (2020). Characteristics of COVID-19 infection in Beijing. Journal of Infection. https://doi.org/10.1016/j.jinf.2020.02.018

Van Griensven, J., Edwards, T., De Lamballerie, X., Semple, M. G., Gallian, P., Baize, S., … Haba, N. (2016). Evaluation of convalescent plasma for Ebola virus disease in Guinea. New England Journal of Medicine. https://doi.org/10.1056/NEJMoa1511812

WHO Global Infection Prevention and Control Network. (2020). Infection prevention and control during health care when COVID-19 is suspected. WHO. Retrieved from https://www.who.int/publications-detail/infection-prevention-and-control-during-health-care-when-novel-coronavirus-(ncov)-infection-is-suspected-20200125

Ye, M., Fu, D., Ren, Y., Wang, F., Wang, D., Zhang, F., … Lv, T. (2020a). Treatment with convalescent plasma for COVID-19 patients in Wuhan, China. Journal of Medical Virology. https://doi.org/10.1002/jmv.25882

Ye, M., Fu, D., Ren, Y., Wang, F., Wang, D., Zhang, F., … Lv, T. (2020b). Treatment with convalescent plasma for COVID-19 patients in Wuhan, China. Journal of Medical Virology, (April), 1–12. https://doi.org/10.1002/jmv.25882

Zhai, P., Ding, Y., Wu, X., Long, J., Zhong, Y., & Li, Y. (2020a). The epidemiology, diagnosis and treatment of COVID-19. International Journal of Antimicrobial Agents. https://doi.org/10.1016/j.ijantimicag.2020.105955

Zhai, P., Ding, Y., Wu, X., Long, J., Zhong, Y., & Li, Y. (2020b). The epidemiology, diagnosis and treatment of COVID-19. International Journal of Antimicrobial Agents. https://doi.org/10.1016/j.ijantimicag.2020.105955 LK

Zhou, M., Zhang, X., & Qu, J. (2020). Coronavirus disease 2019 (COVID-19): a clinical update. Frontiers of Medicine. https://doi.org/10.1007/s11684-020-0767-8


Article Metrics

Abstract view : 2417 times
PDF - 359 times

DOI: https://doi.org/10.26714/medart.3.1.2021.53-60

Refbacks

  • There are currently no refbacks.


Contact

Faculty of Medicine, Universitas Muhammadiyah Semarang
Jl. Kedungmundu Raya No. 18, Semarang, Indonesia
Email: medica.arteriana@unimus.ac.id