Association of Family History, Body Mass Index, and Exercise Regularity with HbA1c Status in Type 2 Diabetes Melitus Patients

Riandini Aisyah(1*), Nurhasan Agung Prabowo(2)


(1) Faculty of Medicine, Universitas Muhammadiyah Surakarta, Surakarta, Indonesia
(2) Department of Internal Medicine, Universitas Sebelas Maret Hospital, Surakarta, Indonesia
(*) Corresponding Author

Abstract


Background:  Urban life, especially in Surakarta, is easy to access and full of high-carbohydrate food and drink. This has increased unhealthy behavior and diets. The prevalence of diabetes Mellitus (DM) in Surakarta is growing, reaching 24% in 2021. Physical exercise and poor diet are important risk factors for DM, coupled with genetics, causing obesity. HbA1c levels periodically assess DM patients' glycemic management.

Objective: This study aims to determine the association between family history, body mass index, and regular exercise with HbA1c status in type 2 DM patients at UNS Surakarta Hospital.

Methods: The research was an observational study; 24 patients diagnosed with type 2 DM were recruited from the outpatient clinic of Universitas Sebelas Maret Hospital, Surakarta, Indonesia, in October 2021. Measurements were conducted to determine their HbA1c level by enzymatic methods and body mass index by measuring body weight and height, and they were questioned regarding their physical exercise and family history of diabetes. The data collected were analyzed using multiple logistic regression to ascertain the association between family history, body mass index, and exercise regularity with HbA1c status.

Results: The findings indicated no statistically significant association between genetic background, body mass index, and exercise frequency with HbA1c status (p>0.05).

Conclusion: This research shows that genetic history, body mass index, and exercise regularity are not associated with HbA1c status in type 2 DM in included subjects.


Keywords


Type 2 DM; genetic back-ground; obesity; exercise; HbA1c

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References


World Health Organization. Classification and Diagnosis of Diabetes : Standards of Medical Care in Diabetes 2019. 2019;42(January):13–28.

Kementerian Kesehatan RI. Hasil Utama Riskesdas 2018. Jakarta: Badan Penelitian dan Pengembangan Kesehatan; 2018.

BPJS Kesehatan. Utilisation Review (UR) RS Universitas Sebelas Maret Periode Januari-November 2021. 2022.

Selman A, Burns S, Reddy AP, Culberson J, Reddy PH. The Role of Obesity and Diabetes in Dementia. Int J Mol Sci. 2022;23(16):9267.

Trisnadewi N.W, Widarsih N.L, Pramesti TA. Hubungan Obesitas Sentral dan Aktivitas Fisik dengan Kejadian Diabetes Melitus Tipe 2 di Puskesmas III Denpasar Utara. BMJ. 2019 August;6(2):119–129

Rudi A & Kwureh H.N. Faktor Risiko yang Mempengaruhi Kadar Gula Darah Puasa pada Pengguna Layanan Laboratorium. Wawasan Kesehatan. 2017 Jan;3(2):33-399. Koh H Chow E. Insulin Clearance in Obesity and Type 2 Diabetes. 2022.

Sari NN. Hubungan obesitas sentral dengan kejadian diabetes mellitus tipe II. Jurnal Keperawatan Sai Betik. 2018 Okt;14(2):157–161

Cheng L, Wang J, Dai H, et al. Brown and beige adipose tissue: a novel therapeutic strategy for obesity and type 2 diabetes mellitus. Adipocyte. 2021;10(1):48-65.

Chobot A. Obesity and diabetes — Not only a simple link between two epidemics. Diabetes Metab Res Rev. 2018; 34:e3042.2018;(June):1–9.

Selman A, Burns S, Reddy AP, Culberson J, Reddy PH. The Role of Obesity and Diabetes in Dementia. Int. J. Mol. 2022; 23, 9267(August):1-25.

Koh H Chow E, Cao C, Mittendorfer B. Insulin Clearance in Obesity and Type 2 Diabetes. Int. J. Mol. Sci. 2022; 23, 596(Jan):1-18.

Soelistijo S, Novida H, Rudijanto A, et al. Konsesus Pengelolaan Dan Pencegahan Diabetes Melitus Tipe2 Di Indonesia 2015.; 2015.

Kurniawaty E, Yanita B, Biokimia B, Kedokteran F, Lampung U. Faktor-Faktor yang Berhubungan dengan Kejadian Diabetes Melitus Tipe II. Majority. 2016;5(April):27-31.

Ardiani HE, Astika T, Permatasari E. Obesitas , Pola Diet , dan Aktifitas Fisik dalam Penanganan Diabetes Melitus pada Masa Pandemi Covid-19. MJNF. 2021;2(1):1-12.

Nurayati L, Adriani M. Hubungan Aktifitas Fisik dengan Kadar Gula Darah Puasa Penderita Diabetes Melitus Tipe 2. Amerta Nutr. 2017:80-87.

Sanda A, Mangarengi F, Pakasi RDN. Kadar Asam Urat Berkorelasi dengan Kadar Hemoglobin Terglikolisasi ( HbA1c ) Pasien Diabetes Melitus tipe 2. CDK-265; 2018;45(6):405–7.

Gahung RY, Pandelaki K, Moeis ES. Hubungan kadar HbA1C dengan Estimasi Filtrasi Glomerulus pada Pasien DM Tipe 2. Jurnal e-Clinic. 2016;4:2–5. 18.

Kurniawaty E, Yanita B, Biokimia B, Kedokteran F, Lampung U. Faktor-Faktor yang Berhubungan dengan Kejadian Diabetes Melitus Tipe II Risk Factors Related Type 2 Diabetes Mellitus Evidance. Majority. 2016;5(April):27–31.

Pillon NJ, Loos RJF, Marshall SM, Zierath JR. Metabolic consequences of obesity and type 2 diabetes: Balancing genes and environment for personalized care. Cell 184. 2021 March: 1530-1544.

Barrès R, Zierath JR. The role of diet and exercise in the transgenerational epigenetic landscape of T2DM. Nat Rev Endocrinol. 2016;12(8):441-451.

Ling C, Rönn T. Epigenetics in Human Obesity and Type 2 Diabetes. Cell Metab. 2019;29(5):1028-1044.

Liberty IA. Hubungan Obesitas dengan Kejadian Prediabetes pada Wanita Usia Produktif. Jurnal Kedokteran dan Kesehatan. 2016;3(2):108–113.

Masi G & Oroh W. Hubungan Obesitas dengan Kejadian Diabetes Melitus di Wilayah Kerja Puskesmas Ranomut Kota Manado. e-journal Keperawatan. 2018;6(1):1-6

Permatasari ND, Rachmawati B, Riansari A, Limijadi EKF. Hubungan HbA1c dengan CRP pada Penderita Diabetes Melitus Tipe-2 dengan Obesitas dan Tanpa Obesitas. Journal of Nutrition College. 2020;9:267–72.

Nugroho PS, Wijayanti AC. Indeks Masa Tubuh dan Kaitannya dengan Diabetes Melitus pada Umur > 15 Tahun di Indonesia, Studi Data Survei Kehidupan Keluarga Indonesia V. JPKMI. 2018 Apr 3;5(1):12.

Putri AES, Larasati T. Hubungan Obesitas dengan Kadar HbA1c Pasien Diabetes Melitus Tipe 2 di Laboratorium Patologi Klinik Rumah Sakit Umum Daerah Abdul Moeloek Provinsi Lampung. Medical Journal of Lampung University. 2013 Februari, 2(4):9.

Regina CC, Mu A, Fitriany E. Systematic Review tentang Pengaruh Obesitas terhadap Kejadian Komplikasi Diabetes Melitus. Jurnal Verdure. 2021;3(1):8–17.

Chobot A, Górowska‐Kowolik K, Sokołowska M, Jarosz‐Chobot P. Obesity and diabetes—Not only a simple link between two epidemics. Diabetes Metab Res Rev. 2018;34(7):e3042.

Ardiani HE, Permatasari TAE, Sugiatmi S. Obesitas, Pola Diet, dan Aktifitas Fisik dalam Penanganan Diabetes Melitus pada Masa Pandemi Covid-19. Muhammadiyah J Nutr Food Sci MJNF. 2021;2(1):1.

Otto-Buczkowska E, Jainta N. Pharmacological Treatment in Diabetes Mellitus Type 1 – Insulin and What Else? Int J Endocrinol Metab. 2017;16(1).

Cheng L, Wang J, Dai H, et al. Brown and beige adipose tissue : a novel therapeutic strategy for obesity and type 2 diabetes mellitus. Adipocyte. 2021;10(1):48-65.


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DOI: https://doi.org/10.26714/magnamed.12.1.2025.1-8

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